• Large Vessel Hemodynamics
  • Coronary Hemodynamics
  • Left Atrial Appendage
  • Right Atrium Hemodynamics
  • Radial Basis Functions
  • In-silico Hemodynamics and Biomechanics Finite Element Analysis

Our research focuses on understanding blood flow through cardiovascular structures and is intended for translational applications.

Integrating different approaches, such as medical imaging, computational fluid dynamics, finite element analysis and tissue modeling, we aim to answer both clinical and basic science questions.

Blood velocity at systolic peak at different stages of ascending aortic aneurysms formation



Image Analysis and Fusion

Our image analysis activities are carried out to provide advanced tools to obtain non invasive measurements of complex cardiovascular conditions during a surgery planning.

We are developing a workflow based on a multimodal imaging approach to extract functional information and anatomical cardiovascular structure by using platform-free approaches.


3D Left Atrial Appendage (LAA) surface models extracted from 3D ECHO and 3D CT and multimodal imaging fusion


EU Fundings
DITAIDD – FF4EUROHPC – Exp. 1006, Cloud – Based Hpc Platform To To Generate A Dt Of The Human Airways, Paving The Way For Personalised Medicine In Customised Drug Delivery.

COPERNICUS – FF4EUROHPC – Exp. 1006, Cloud – Based Hpc Platform To Support Systemic-Pulmonary Shunting Procedures

REPAIR– H2020-Eu.1.2.2. – Fet Proactive

MEDITATE– Horizon 2020 Research And Innovation Programme Marie Skłodowska-Curie

4R TENDER – Horizon 2020 (Jrc/Ipr/2018/F.3/0035/Oc)

National/Regional Fundings
Vobilai4H – Regione Toscana Bando Bando Assegni Di Ricerca Anno 2021

Fastaaa – Italian Supercomputing Resource Allocation – Cineca, Iscra C

Mybreathingheart – Regione Toscana Bando Covid19

Imec – Ministero Della Salute Rf 2020-2023

Precise – Regione Toscana Bando Salute Rf 2020-2023

Pensami – Regione Toscana Bando Salute Rf 2020-2023

3D Virtual Baby Heart – Ministero Della Salute Rf 2019-2021

Private Corporate/Foundation


Past projects
VIVIR Virtual and Augmented Reality Support for Transcatheter Valve Implantation by using Cardiovascular MRI (2017-2019) Project founded by the Italian Ministry of health (Ministero della Salute, PE-2013-02357974 grant).

ValveTech Realization of a polymer aortic valve of new conception and implantable through robotic platform with minimally invasive surgery techniques (2016-2018) Project founded by the Tuscany Region.


Journal Papers

E. Gasparotti et al, Numerical investigation on circular and elliptical bulge tests for inverse soft tissue characterization, Biomechanics and Modeling in Mechanobiology, 2023, in press

A. Meloni et al, Dual Source Photon-Counting Computed Tomography – Part III: Clinical Overview of Vascular applications beyond Cardiac and Neuro imaging, J. Clin. Med. 2023;12(11):3798.

F. Cademartiri et al, Dual Source Photon-Counting Computed Tomography—Part II: Clinical Overview of Neurovascular Applications, J. Clin. Med. 202312(11), 3626

F. Cademartiri et al, Dual Source Photon-Counting Computed Tomography – Part I: Clinical Overview of Cardiac CT and Coronary CT Angiography applicationsJ. Clin. Med. 2023, 12(11), 3627

S. Scalera et al, 3D Printed Model-guided Neonatal Trans-catheter Closure of Left Main Coronary Artery-to-Right Ventricle Fistula, JACC Case Reports, 2023, 16(101869)

K. Calò et al, Impact of wall displacements on the large-scale flow coherence in ascending aorta, Journal of Biomechanics, 2023, DOI:

B.M. Fanni et al, An integrated in-vitro and in-silico workflow to study the pulmonary bifurcation hemodynamics, Computers and Fluids, 260, 105912, DOI:

A. Mariotti et al, In-vitro analysis of the hemodynamics in the ascending thoracic aorta: sensitivity to the experimental setup, Appl. Sci. 2023,

B.M. Fanni et al, Uncertainty Quantification in the In Vivo Image-Based Estimation of Local Elastic Properties of Vascular Walls, Journal of Cardiovascular Development and Disease, J. Cardiovasc. Dev. Dis. 2023, 10(3), 109;

C. Zirafa et al, Surgical management of teratoma located in pretracheal retrocaval space: from pre-operative 3D reconstruction to robotic surgery, Journal of Video-Assisted Thoracic Surgery, Vol 8, 1-5, 2023, doi: 10.21037/vats-22-36

S. Celi et al, An image-based approach for the estimation of arterial local stiffness in vivo, Front. Bioeng. Biotechnol. Sec. Biomechanics Volume 11 – 2023 | doi: 10.3389/fbioe.2023.1096196

M. Cantinotti et al, Characterization of Aortic Flow Patterns by High-Frame Rate Blood Speckle Tracking Echocardiography in Children, J Am Heart Assoc, 18;12(8), 2023

M. Koch et al, HPC+ in the medical field: Overview and current examples, Technology and Health Care, 2023 : 1 – 15, doi: 10.3233/THC-229015


F. Bardi et al, A Hybrid Mock Circulatory Loop for fluid dynamic characterisation of 3D anatomical phantoms, IEEE Transactions on Biomedical Engineering, 10.1109/TBME.2022.3224581

Celi, S., et al, Advanced Non-animal Models in Biomedical Research, EUR 30334/5 EN, Publications Office of the European Union, Luxembourg, 2022, ISBN 978-92-76-56984-8, doi:10.2760/276664, JRC130702.

M.N. Antonuccio et al, Towards the 2D velocity reconstruction in abdominal aorta from Color-Doppler Ultrasound, Medical Engineering and Physics, in press

A. Pizzuto et al, Transcatheter Treatment of Native Idiopathic Multi-loculated Aortic Aneurysm guided by 3D Printing Technology, J Am Coll Cardiol Case Report, in press

B.M. Fanni et al, Introduction of a Novel Image-Based and Non-Invasive Method for the Estimation of Local Elastic Properties of Great Vessels, Electronics 2022, 11(13), 2055

E. Kardampiki et al, The hemodynamic effect of modified Blalock-Taussig shunt morphologies: A computational analysis based on reduced order modeling, Electronics 2022, 11(13), 1930

K. Capellini et al., A decision-support informatics platform for minimally invasive aortic valve replacement, Electronics 2022, 11, 1902

E. Gasparotti et al, Image-based modelling and numerical simulations of the Cardioband procedure for mitral valve regurgitation repair, Computer Methods in Applied Mechanics and Engineering, 2022, 394, 114941

G. Santoro et al, Transcatheter Treatment of Ascending Aorta Pseudo-aneurysm Guided by 3D-model Technology, J Am Coll Cardiol Case Rep. 2022 , 4 (6) 343–347

E. Vignali et al, High versatility left ventricle pump and aortic mock circulatory loop development for patient specific haemodynamic in-vitro analysis, ASAIO, 2022, doi: 10.1097/MAT.0000000000001651


F. Mastorci et al, A New Web Score to Predict Health Status in Paediatric Patients with Chronic Diseases: Design and Development of the PENSAMI Study, Children 2021, 8(12), 1094; doi: 10.3390/children8121094

S. Celi et al, On the role and effects of uncertainties in cardiovascular in-silico analyses, Frontiers in Medical Technology, Front. Med. Technol. 3:748908. doi: 10.3389/fmedt.2021.748908

E. Vignali et al, Fully-coupled FSI computational analyses in the ascending thoracic aorta using patient-specific conditions and anisotropic material properties, Frontiers in Physiology Computational Physiology and Medicine, doi: 10.3389/fphys.2021.732561 2021

M.Cuman et al, 3D Model-guided Transcatheter Closure of Ascending Aorta Pseudoaneurysm with the novel AmplatzerTM TrevisioTM Intravascular Delivery System, Catheterization and Cardiovascular Interventions, 2021, 10.1002/ccd.29937

M.N. Antonuccio et al, Effects of uncertainty of outlet boundary conditions in a patient-specific case of aortic, Annals of Biomedical Engineering, 2021, 10.1007/s10439-021-02841-9

A. Mariotti et al, Hemodynamics and stresses in numerical simulations of the thoracic aorta: stochastic sensitivity analysis to inlet flow-rate waveform, Computers and Fluids, 230(15), 105123, doi:, 2021

M.F. Santarelli et al, The core of medical imaging: state of the art and perspectives on the detectors, Electronics, 10(14), 1642, doi: 10.3390/electronics10141642, 2021

G. Santoro et al, Transcatheter Treatment of “Complex” Aortic Coarctation Guided by Printed 3D Model, JACC: CASE REPORTS, 3 (6), 900-904, doi: /10.1016/j.jaccas.2021.04.036, 2021

F. di Bartolo et al, Numerical simulations of light scattering in soft anisotropic fibrous structures and validation of a novel optical setup from fibrous media characterization, Electronics, 10(5), 579; doi: 10.3390/electronics1010000, 2021

E. Vignali et al, Development and realization of an experimental bench test for Small Angle Light Scattering and Biaxial Traction analysis of tissues, Electronics , 10(4), 386, doi: 10.3390/electronics10040386, 2021

L. Geronzi et al, High fidelity fluid-structure interaction by radial basis functions mesh adaption of moving walls: a workflow applied to an aortic valve, Journal of Computational Science, 2021, 51, j.jocs.2021.101327

A. Cavallo et al, Fabrication and in-vitro characterization of a Polymeric Aortic Valve for Minimally Invasive Valve Replacement, Journal of the Mechanical Behavior of Biomedical Materials, doi: 10.1016/j.jmbbm.2020.104294, 2021


E. Vignali et al, Correlation between micro and macrostructural biaxial behavior of aTAA: a novel experimental technique, Medical Engineering & Physic, 86, 78-85, 2020, doi: 10.1016/j.medengphy.2020.10.012

K. Capellini et al, A novel formulation for the study of the ascending aortic fluid dynamics with in vivo data, Medical Engineering & Physic, 2020, doi: 10.1016/j.medengphy.2020.09.005A

Pizzuto et al, 3D model-guided transcatheter closure of left ventricular pseudoaneurysm, a case series, J Cardiovasc Med, 2020, doi: 10.2459/JCM.0000000000001114

M. Cuman et al, 3D model-guided trans-catheter closure of a complex aortic paravalvular leak, J Cardiovasc Med, 2020, doi: 10.2459/JCM.0000000000001082.

B.M. Fanni et al, A Proof of Concept of a Non-Invasive Image-Based Material Characterization Method for Enhanced Patient-Specific Computational Modeling, Cardiovascular Engineering and Technology, 2020, doi: 10.1007/s13239-020-00479-7

S. Celi et al, 3D printing in modern cardiology, Current Pharmaceutical Design, 2020, doi: 10.2174/1381612826666200622132440

M.E. Biancolini et al, Fast CFD evaluation of hemodynamics assisted by RBF mesh morphing and reduced order models: the case of aTAA modelling, Int J Interact Des Manuf 14, 1227–1238 (2020) doi: 10.1007/s12008-020-00694-5

F. Di Bartolo et al, Penetration capability of near infrared Laguerre-Gaussian vortex beams through highly scattering media, Optics Letters, 2020, doi: 10.1364/OL.387998

A. Zaccaria et al, Left atrial appendage occlusion device: Development and validation of a finite element model, Medical Engineering & Physics, 82, 104-118, 2020, doi: 10.1016/j.medengphy.2020.05.019

B.M. Fanni et al, Correlation between LAA Morphological Features and Computational Fluid Dynamics Analysis for Non-Valvular Atrial Fibrillation Patients, Appl. Sci., 10, 1448, 2020, doi: 10.3390/app10041448

L. Geronzi et al, Advanced Radial Basis Functions Mesh Morphing for High Fidelity Fluid-Structure Interaction with Known Movement of the Walls: simulation of an Aortic Valve. V. V. Krzhizhanovskaya et al. (Eds.): ICCS 2020, LNCS 12142, pp. 280–293, 2020, doi: 10.1007/978-3-030-50433-5_22

Vignali, E., Gasparotti, E., Capellini, K., Fanni, B. M., Landini, L., Positano, V., & Celi, S., Modelling biomechanical interaction between soft tissue and soft robotic instruments: importance of constitutive anisotropic hyperelastic formulations, The International Journal of Robotics Research, 2020 doi: 10.1177/0278364920927476.


E. Vignali et al. Design, simulation and fabrication of a 3D printed pump mimicking the left ventricle motion. The International Journal of Artificial Organs, (2019), doi: 10.1177/0391398819856892

G. Vivoli et al, Simultaneous functional and morphological assessment of left atrial appendage by 3D virtual models, Journal of Healthcare Engineering, (2019), doi: 10.1155/2019/7095845


K. Capellini et al, Computational fluid dynamic study for aTAA hemodynamics: an integrated image-based and RBF mesh morphing approach, J Biomech Eng, (2018) doi: 10.1115/1.4040940

E. Gasparotti et al, A 3D printed melt-compounded antibiotic loaded thermoplastic polyurethane heart valve ring design: an integrated framework of experimental material tests and numerical simulations, Int J Polymeric Materials and Polymeric Biomaterials, (2018), doi: 10.1080/00914037.2018.1525717

A. Boccadifuoco et al, Validation of numerical simulations of thoracic aorta hemodynamics: comparison with in-vivo measurements and stochastic sensitivity analysis, Cardiovasc Eng Tech (2018), doi: 10.1007/s13239-018-00387-x

A. Boccadifuoco, et al, Impact of uncertainties in outflow boundary conditions on the predictions of hemodynamic simulations of ascending thoracic aortic aneurysms. Computers and Fluids (2018), doi: /10.1016/j.compfluid.2018.01.012

S. Berti et al, First-in-Human Percutaneous Left Atrial Appendage Occlusion Procedure Guided by Real-Time 3-Dimensional Intracardiac Echocardiography, JACC: Cardiovascular Interventions, 11(21), 2018, doi: 10.1016/j.jcin.2018.08.023


S Celi, et al. Multimodality Imaging for Interventional Cardiology. Current Pharmaceutical Design (2017), doi: 10.2174/1381612823666170704171702

C. Chiastra et al, Reconstruction of stented coronary arteries from optical coherence tomography images: Feasibility, validation, and repeatability of a segmentation method, PLoS One (2017), doi: 10.1371/journal.pone.0177495

Conference Abstracts published on indexed Journals
A. Mariotti et al, Integrating in-vivo Data in CFD Simulations and in in-vitro Experiments of the Hemodynamic in Healthy and Pathologic Thoracic Aorta, Conference proceedings, Bioinformatics and Biomedical Engineering, 9th International Work-Conference, IWBBIO 2022, Maspalomas, Gran Canaria, Spain, June 27–30, 2022, Proceedings, Part IIK. Capellini et al, 3D printing and 3D virtual models for surgical and percutaneous planning of Congenital Heart Diseases, VISAPP 2020 10.5220/0009160702810287

K. Capellini et al, 3D printing and 3D virtual models for surgical and percutaneous planning of Congenital Heart Diseases, VISAPP 2020 10.5220/0009160702810287

B.M. Fanni et al, Importance of left atrium fluid dynamics for the planning of LAA closure procedure: an integrated computational fluid dynamics and morphological study, European Heart Journal 2018;39 (Issue Supplement 1):1290 ESC 2018, Munich (ESC Best Poster Awards)

E Vignali, et al A morphological and mechano-biological comparison between ascending thoracic aneurysms with bicuspid and tricuspid valves via in-vivo and ex-vivo investigation. European Heart Journal 2017;38(Suppl. 1):825-826 (P3975) (ESC Travel Awards)

A. Malacarne et al, High-Speed 2D-Scan for Optical Coherence Tomography, 20th Italian National Conference on Photonic Technologies (Fotonica 2018), doi: 10.1049/cp.2018.1656

E. Gasparotti et al, Analysis of non-animal methods and models for research in cardiovascular disease, Biomedical Science and Engineering 2019; volume 3(s3):112, doi: 10.4081/bse.2019.112

M.N. Antonuccio et al, Effects of the distribution in space of the velocity-inlet condition in hemodynamic simulations of the thoracic aorta, Rojas I., Valenzuela O., Rojas F., Herrera L., Ortuño F. (eds) Bioinformatics and Biomedical Engineering. IWBBIO 2020. Lecture Notes in Computer Science, vol 12108. Springer, Cham, doi: 10.1007/978-3-030-45385-5_6

E. Vignali et al, Development of a fully controllable real-time pump to reproduce left ventricle physiological flow, Carcaterra A., Paolone A., Graziani G. (eds) Proceedings of XXIV AIMETA Conference 2019. AIMETA 2019. Lecture Notes in Mechanical Engineering. Springer, Cham, doi: 10.1007/978-3-030-41057-5_74

A. Mariotti et al, Numerical and experimental uncertainty quantification study of ascending thoracic aortic aneurysm hemodynamics, Carcaterra A., Paolone A., Graziani G. (eds) Proceedings of XXIV AIMETA Conference 2019. AIMETA 2019. Lecture Notes in Mechanical Engineering. Springer, Cham, doi: 10.1007/978-3-030-41057-5_73

G Turini et al, Software Framework for VR-Enabled Transcatheter Valve Implantation in Unity, Lecture Notes in Computer Science, 2019;11613:376-384, doi. 10.1007/978-3-030-25965-5_28

G Turini et al, Patient specific virtual and physical simulation platform for surgical robot movability evaluation in single-access robot-assisted minimally-invasive cardiothoracic surgery, Lecture Notes in Computer Science, 211-220, 2017

Book Chapters
S. Celi et al, Prototipazione rapida da immagini per una medicina personalizzata, Capitolo,”Immagini biomediche: nuove tendenze in tecnologia, metodi e applicazioni”, ed. PATRON, 2018 (Capitolo 18, pag: 223-234)

L. Landini et al, Registrazione e fusione di immagini multimodali, Capitolo, “Immagini biomediche: nuove tendenze in tecnologia, metodi e applicazioni”, ed. PATRON, 2018 (Capitolo 3, pag: 37-48)

S. Celi and S. Berti, Biomechanics and FE Modelling of Aneurysm: Review and Advances in Computational Models, Aneurysm, Yasuo Murai, IntechOpen, doi: 10.5772/46030

Conference Proceedings
M.N. Antonuccio et al, Towards the translation of patient-specific CFD simulations into clinics: an integrated approach for a non-invasive study of aortic coarctation, VPH 2020

L. Geronzi et al, A novel fast high-fidelity numerical approach based on rbf mesh morphing to evaluate the performances of a polymeric heart valve, ICTAM 2020, in press

M.N. Antonuccio et al, Numerical simulation of blood flow in the thoracic aorta: stochastic sensitivity analysis to inlet velocity spatial distribution, ICTAM 2020

F. Di Bartolo, Penetration Depth Increase of Near Infrared Vortex Light through Turbid Media, CLEO 2020

B.M. Fanni et al, A novel image-based formulation for enhanced patient-specific in silico simulations of cardiovascular interventions, International CAE Conference 2019

K. Capellini et al, A novel FSI approach for the study of the aorta hemodynamics: an integrated imaged based and RBF mesh morphing technique, International CAE Conference 2019

F. Danielli et al, Numerical Model of a Left Atrial Appendage Occluder, International CAE Conference 2019

E. Gasparotti et al, A novel FSI-RBF mesh morphing environment to design a new polymeric aortic valve, International CAE Conference 2019

M.N. Antonuccio et al, An integrated CFD and UQ approach to assess hemodynamic alteration in the Aortic Coarctation, International CAE Conference 2019

E. Vignali et al, In silico evaluation of a patient specific ATAA case through experimental mechano microstructural characterization, International CAE Conference 2019

K. Capellini et al, In-silico assessment of thrombosis risk: a CFD study of left atrial and left atrial appendage, ESB-Ita 2019

K. Capellini et al, A coupled CFD and RBF mesh morphing technique as surrogate for one-way FSI study, ESB-Ita 2019,

B. M. Fanni et al, A corrected formulation for the image-based inferring of patient-specific material properties, ESB-Ita 2019

E. Gasparotti et al, In silico healthcare: first human simulations of Cardioband® procedure for mitral regurgitation, ESB-Ita 2019

E. Vignali et al, Biaxial and optomechanical characterization of soft tissues: a novel setup and experimental tests, ESB-Ita 2019

E. Gasparotti et al, A combined approach of numerical simulation and additive manufacturing technique for in-silico and in-vitro testing of a 3D printing-based aortic polymeric heart valve, SIM AM Proceedings, 2019

B.M. Fanni et al, A numerical and 3D printing framework for the in vivo mechanical assessment of patient-specific cardiovascular structures, SIM AM Proceedings, 2019

A. Mariotti et al, Stochastic analysis of the effect of inlet conditions in the hemodynamics simulation of a thoracic aortic aneurysm, Workshop on Frontiers of Uncertainty Quantification in Fluid Dynamics 11–13 September 2019, Pisa, Italy

M. N. Antonuccio, An integrated approach of uncertainty quantification and 3D MRI techniques in guiding CFD analysis for a non-invasive study of aortic coarctation, Workshop on Frontiers of Uncertainty Quantification in Fluid Dynamics 11–13 September 2019, Pisa, Italy

Conference Abstracts
M.N. Antonuccio et al, Towards the translation of patient-specific CFD simulations into clinics: an integrated approach for a non-invasive study of aortic coarctation, VPH, Parigi, Francia

A. Zaccaria et al, A validation path for a Left Atrial Appendage Occluder, VPH, Parigi, Francia

E. Vignali et al, Development of a custom mock circulatory loop for in-vitro study of patient specific aortic branch, ISMCS 2019, Bologna, Italy

D. Haxhiademi et al, Platelet function tests in VA ECMO patients – Can we read between the lines? ISMCS 2019, Bologna, Italy

B.M. Fanni et al, Indirect evaluation of material properties of large blood vessels based on in silico and in vitro models, ESB 2019 Congress

F. Di Bartolo et al, Optomechanical characterization of soft biological tissues: an integration of biaxial test and sals technique, ESB 2019 Congress

B.M. Fanni et al, A modified formulation of the QA method for inferring materials properties for enhanced patient-specific computational models, BioMedEng 2019

C. Groth et al, The medical digital twin assisted by Reduced Order Models and Mesh Morphing, International CAE conference and exibition, 2018, Vicenza, Italy

F. Falconi, High-Speed 2D-Scan for Optical Coherence Tomography, Fotonica AEIT Italian conference on photonics technologies, 2018

B.M. Fanni et al, 3D printed models for the mechanical characterization of cardiovascular structures, Proceedings of IDBN 2018, pp. 54-56

E. Vignali et al, 3D Printing of an antibiotic-loaded heart valve ring prosthesis in thermoplastic polyurethane: fabrication, testing and simulation, Proceedings of IDBN 2018, pp. 60-62

Z. Manigrasso et al, Design of a novel 3D printed mock cardiac pump: in-silico and experimental evaluation, Proceedings of IDBN 2018, pp. 57-59

Z. Manigrasso et al, A novel 3D printed bioinspired cardiac pneumatic pump: from design to numerical and experimental study, VPH 2018, Zaragoza, Spain, 2018

B.M. Fanni et al, An integrated image-based framework for the mechanical characterization of patient-specific blood vessels, VPH 2018, Zaragoza, Spain, 2018

E. Vignali et al, Towards non-invasive assessment of human aortic tissue microstructure: Diffusion Tensor Imaging for collagen fiber detection, GNB, Milano, 2018, pp: 1-4

E. Vignali et al, Ascending thoracic aortic FE simulation by integrating patient-specific data from imaging, mechanical properties and histological data, WCB 2018

E. Gasparotti et al, Towards a patient-specific finite element simulation of Cardioband procedure for the treatment of mitral regurgitation, WCB 2018

B.M. Fanni et al, Image-based mechanical characterization of large blood vessels for patient-specific simulations, WCB 2018

A. Boccadifuoco, A. Mariotti, K. Capellini, S. Celi, M.V. Salvetti, Impact of uncertainties in inlet conditions on the hemodynamic simulation in ascending thoracic aortic aneurysms, WCB 2018

E. Gasparotti et al, Melt Compounded Biocompatible Thermoplastic Polyurethane (TPU) for the Engineering of 3D printed Aortic Heart Valve Ring: Design, Fabrication, Testing and Simulation, ISBPPB 2018

E Vignali, K Capellini, P Losi, M Murzi, PA Farneti, V Positano, L Landini, S Celi. A morphological and histo-mechanical study for ascending aorta aneurisms in BAV and TAV patients. 23rd Congress of the European Society of Biomechanics, July 2 – 5, 2017, Seville, Spain

E Gasparotti, E Vignali, K Capellini, G Vivoli, AG Cerillo, V Positano, S Berti, L Landini, S Celi. A FE tool to simulate a trans-catheter anchor-based system for mitral valve regurgitation. Proceedings of the VII Annual Meeting Italian Chapter of the European Society of Biomechanics 2017:57

BM Fanni, E Gasparotti, S Celi, V Positano, F Faita, N Di Lascio, L Landini, S Schievano, C Capelli. Image-based mechanical characterization of large blood vessels. Proceedings of the VII Annual Meeting Italian Chapter of the European Society of Biomechanics 2017:35

S. Porziani et al, Hemo-Elastic study of ascending thoracic aorta aneurysms through RBF mesh morphing, CAE Conference 2018

G Vivoli, E Gasparotti, M Rezzaghi, M Mariani, V Positano, S Berti, L Landini, S Celi. 3D left atrial appendage modelling: a multimodal imaging approach. Proceedings of the VII Annual Meeting Italian Chapter of the European Society of Biomechanics 2017:59

K Capellini, E Costa, ME Biancolini, E Vignali, V Positano, L Landini, S Celi. An image-based and RBF mesh morphing CFD simulation for aTAA hemodynamic. Proceedings of the VII Annual Meeting Italian Chapter of the European Society of Biomechanics 2017:25

Selection of past publications
A Boccadifuoco, A Mariotti, S Celi, N Martini, MV Salvetti, Uncertainty quantification in numerical simulations of the flow in thoracic aortic aneurysms. Proceedings of the 7th European Congress on Computational Methods in Applied Sciences and Engineering, ECCOMAS Congress, 3:6226-6249, 2016

AG Cerillo, T Gasbarri, S Celi, M Murzi, G Trianni, M Ravani, M, Solinas, S Berti, Transapical Transcatheter Valve-in-Valve Implantation for Failed Mitral Bioprostheses: Gradient, Symptoms, and Functional Status in 18 High-Risk Patients Up to 5 Years, Ann Thorac Surg. 2016, 102(4):1289-95.

Celi S, Berti S., Three-dimensional sensitivity assessment of thoracic aortic aneurysm wall stress: a probabilistic finite-elementstudy. Eur J Cardiothorac Surg. 2014, 45(3):467-75

Celi S, Berti S., In-vivo segmentation and quantification of coronary lesions by optical coherence tomography images for a lesion type definition and stenosis grading. Med Image Anal. 2014, 18(7): 1157-68

Celi S, Vaghetti M, Palmieri C, Berti S., Coronary calcium analysis by OCT: looking forward an imaging algorithm for an automatic 3D quantification. Int J Cardiol. 2013, 168(3): 2958-60


MSc Theses
MSc theses in Bioengineering can be developed at BioCardioLab on several topics, as:

  • Numerical simulations in the biomedical field
  • Biomedical image analysis
  • Design, simulation and fabrication of biomedical devices

Thesis @ BCL
Fell free to contact the BioCardioLab staff (Simona Celi, Vincenzo Positano, Luigi Landini) for further information and visits to the laboratory.

Theses Proposals with Laboratoire Sainbiose (UMR INSERM-U1059 – Mines Saint-Etienne)
Multiscale modeling of mass transport across large blood vessels. Investigations in the domain of arterial mechanobiology, in collaboration with vascular surgeons.
Theses Proposals with UCL (London)
Fluid structure interaction of flow in patient geometry of congenital aorta In this analysis we perform fluid-structure interaction (FSI) simulations on patient specific geometries of patient diagnosed with Hypoplastic Left Heart Syndrom (HLHS) disease. Patients suffering from this condition present an underdevelopped aorta which needs to be repaired (reconstructed) using additional biocompatible material. The project is based on a computational modelling approach using LS-Dyna software to design the FSI simulation along with other tools to pre- and post-process the geometry and results. Good understanding of basics of fluid flow and structural mechanics is required. Eventual experimental set-up can be built towards the end of the project in order to validate computational results.
Theses Proposals with UNIPI (Dep. of Aerospace Engineering)
Study of Numerical Simulations of Thoracic Aorta Hemodynamics: Comparison with In Silico Measurements and Stochastic Sensitivity Analysis
Theses Proposals with FUJIFILM-VisualSonics Amsterdam, The Netherlands
(Remote + Onsite/Industrial Visit)
Development of AI Tools for Ultrasound (US) & Photoacoustic (PA) Image Visualization and Quantification

The goal of this project is to develop a framework to optimize the 3D visualization and quantification of high resolution USPA imaging. In particular: design, implementation and validation of ML tools for USPA image segmentation, visualization and quantification. The project is part of an extraordinary industrial experience with possibility to assist in-vivo experiments with the USPA technology in our lab in Amsterdam. You will be working closely with a PhD student and R&D manager. Due to current travel restrictions, we can start remotely and with possibility in the near future to visit us at the European Headquarters in Amsterdam. Further details can be found in the following links:



Running Theses
  • Marilena Mazzoli – Sviluppo di sistemi intelligenti per lo studio della fluidodinamica cardiovascolare mediante reti physically based
  • Stefano Quartieri – Sviluppo di un banco prova per bulge test
  • Chiara D’Alessandro – Shape analysys and FSI dell’LAA
  • Margherita Giannoni – FSI dell’atrio sinistro
  • Edoardo Cheli – studio di sensibilità ai parametri di input mediante tecniche di UQ
  • Gabriele Gallo – Analisi CFD della fluidodinamica della carotide mediante tecniche di UQ
  • Chiara Carabelli – Simulazione numerica del sistema ECMELLA
  • Francesca Dell’Agnello – Tecniche di mesh morphing applicate alla CT
  • Beatrice Donati – Studio delle condizioni di inlet dell’aorta mediante CT gated del ventricolo sinistro
  • Mariarita Vottari – Studio della rigidezza del tessuto aortico da imaging dinamico (CT) mediante tecniche di mesh morphing o inverse FEM
  • Giulia Tosto – Studio in-vitro del gradiente transvalvolare della valvola mitralica patologica e della sua correzione post Mitraclip
  • Claudia Plutino – Studio dell’effetto del dispositivo percutaneo Cardioband sulla riduzione del rigurgito della valvola tricuspide
  • Eleonora Storto – Studio della fluidodinamica dell’aorta su banco prova attraverso la tecnica PIV (Particle Image Velocimetry)
  • Giulia Tosto – Studio in-vitro del gradiente transvalvolare della valvola mitralica patologica e della sua correzione post Mitraclip
  • Lucia Giuggioli – Studio dell’emodinamica degli aneurismi dell’aorta addominale mediante simulazioni CFD e tecniche di mesh morphing
Previous Theses